Anaesthetic effects of chloral hydrate, pentobarbitone and urethane in adult male rats

Anaesthetic effects of chloral hydrate, pentobarbitone and urethane in adult male rats.

Chloral hydrate, pentobarbitone and urethane were evaluated and compared for onset, duration and depth of anaesthesia, cardiovascular and respiratory effects, nociception and mortality in adult male rats. Chloral hydrate (300 and 400 mg/kg) severely depressed the cardiovascular and respiratory systems. Duration of anaesthesia was linearly related to dose, and anaesthetic depth and analgesia wer...

Chloral and Chloral Hydrate

These substances were considered by a previous Working Group, in February 1995 (IARC, 1995). Since that time, new data have become available and these have been incorporated into the monograph and taken into consideration in the present evaluation.

Chloral and Chloral Hydrate

ANAESTHETIC EFFECTS OF MEDETOMIDINE HCl WITH PROPOFOL, KETAMINE AND CHLORAL HYDRATE IN EQUINES

Efficacy of medetomidine HCl anesthesia was evaluated in 48 horses, divided randomly into six groups (n=8). Initially, propofol, ketamine and chloral hydrate were evaluated individually as sole anesthetic drugs in groups A C and E, respectively. Later on the efficacy of medetomidine HCl as pre-anesthetic was assessed by using it in combination with other drugs. In group B, medetomidine HCl was ...

Chloral hydrate

Major uses Chloral hydrate (synthesized in 1832 and introduced into medicine 1869) is the oldest member of sedative-hypnotic drugs. To the same group belong paraldehyde, bromide, urethane, and sulfonal. Metabolite of chloral hydrate, trichloroethanol, is also an excellent hypnotic agent, but is not often used as such due to its physical and irritant properties. At present, chloral hydrate is la...